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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-4
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pubmed:abstractText |
[(11)C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT(1B)) receptors with positron emission tomography (PET). The purpose of this study was to evaluate [(11)C]P943 for this application in humans, and to determine the most suitable quantification method. Positron emission tomography data and arterial input function measurements were acquired in a cohort of 32 human subjects. Using arterial input functions, compartmental modeling, the Logan graphical analysis, and the multilinear method MA1 were tested. Both the two tissue-compartment model and MA1 provided good fits of the PET data and reliable distribution volume estimates. Using the cerebellum as a reference region, BP(ND) binding potential estimates were computed. [(11)C]P943 BP(ND) estimates were significantly correlated with in vitro measurements of the density of 5-HT(1B) receptors, with highest values in the occipital cortex and pallidum. To evaluate noninvasive methods, two- and three-parameter graphical analyses, Simplified Reference Tissue Models (SRTM and SRTM2), and Multilinear Reference Tissue Models (MRTM and MRTM2) were tested. The MRTM2 model provided the best correlation with MA1 binding-potential estimates. Parametric images of the volume of distribution or binding potential of [(11)C]P943 could be computed using both MA1 and MRTM2. The results show that [(11)C]P943 provides quantitative measurements of 5-HT(1B) binding potential.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1559-7016
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pubmed:author |
pubmed-author:CarsonRichard ERE,
pubmed-author:DingYu-ShinYS,
pubmed-author:FrostJ JamesJJ,
pubmed-author:GallezotJean-DominiqueJD,
pubmed-author:HuangYiyunY,
pubmed-author:KimSunheeS,
pubmed-author:MaguireR PaulRP,
pubmed-author:McCarthyTimothyT,
pubmed-author:NabulsiNabeelN,
pubmed-author:NeumeisterAlexanderA,
pubmed-author:Planeta-WilsonBeataB,
pubmed-author:TarunSinghalS,
pubmed-author:WilliamsWendol AWA
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-210
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:19773803-Brain,
pubmed-meshheading:19773803-Chromatography, High Pressure Liquid,
pubmed-meshheading:19773803-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:19773803-Humans,
pubmed-meshheading:19773803-Image Processing, Computer-Assisted,
pubmed-meshheading:19773803-Isotope Labeling,
pubmed-meshheading:19773803-Linear Models,
pubmed-meshheading:19773803-Magnetic Resonance Imaging,
pubmed-meshheading:19773803-Mental Disorders,
pubmed-meshheading:19773803-Models, Statistical,
pubmed-meshheading:19773803-Piperazines,
pubmed-meshheading:19773803-Positron-Emission Tomography,
pubmed-meshheading:19773803-Pyrrolidinones,
pubmed-meshheading:19773803-Radiopharmaceuticals,
pubmed-meshheading:19773803-Receptor, Serotonin, 5-HT1B
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pubmed:year |
2010
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pubmed:articleTitle |
Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans.
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pubmed:affiliation |
PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA. jean-dominique.gallezot@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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