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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-15
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pubmed:abstractText |
A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Two recent studies reported that the threonine allele of this polymorphism might be a risk factor for Parkinson disease (PD) and essential tremor (ET) development. Although PD and ET are considered different entities, they share some clinical and pathological features, suggesting a possible joint etiology. In this study we assess the role of the Thr105Ile variant in PD and ET development, genotyping the variant in a North American Caucasian PD and ET case-control series. Statistical analysis did not identify any significant association between this variant and PD or ET; therefore, our findings do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-10785440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-10899929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-16543934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-17000339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-17117170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-17353225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-17620881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-17985251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-18154359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-18543121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-19289477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-7529327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-9547362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773194-9626774
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-5126
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-4
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:19773194-Adult,
pubmed-meshheading:19773194-Aged,
pubmed-meshheading:19773194-Aged, 80 and over,
pubmed-meshheading:19773194-Essential Tremor,
pubmed-meshheading:19773194-Female,
pubmed-meshheading:19773194-Gene Frequency,
pubmed-meshheading:19773194-Genetic Predisposition to Disease,
pubmed-meshheading:19773194-Genome-Wide Association Study,
pubmed-meshheading:19773194-Genotype,
pubmed-meshheading:19773194-Histamine N-Methyltransferase,
pubmed-meshheading:19773194-Humans,
pubmed-meshheading:19773194-Isoleucine,
pubmed-meshheading:19773194-Male,
pubmed-meshheading:19773194-Middle Aged,
pubmed-meshheading:19773194-Parkinson Disease,
pubmed-meshheading:19773194-Polymorphism, Genetic,
pubmed-meshheading:19773194-Psychiatric Status Rating Scales,
pubmed-meshheading:19773194-Threonine
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pubmed:year |
2010
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pubmed:articleTitle |
Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
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pubmed:affiliation |
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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