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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
47
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pubmed:dateCreated |
2009-11-2
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pubmed:databankReference |
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pubmed:abstractText |
Dosage-sparing strategies, adjuvants and alternative substrates for vaccine production are being explored for influenza vaccine development. We assessed the safety and immunogenicity of a Vero cell culture-grown inactivated whole virus influenza A/H5N1 vaccine with or without aluminum hydroxide adjuvant [Al(OH)(3)] in healthy young adults. Vaccines were well tolerated, but injection site discomfort was more frequent in groups receiving Al(OH)(3). Dose-related increases in serum antibody levels were observed. Neutralizing antibody titers varied significantly when tested by two different laboratories. Al(OH)(3) did not enhance HAI or neutralizing antibody responses, and contributed to increased injection site pain. Because influenza antibody titers vary significantly between different laboratories, international standardization of assays is warranted.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/M01 RR-00070,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR-00095,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000070-38,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000095-41,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR165001,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI025461,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI025462,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI025463,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI025465,
http://linkedlifedata.com/resource/pubmed/grant/N01-AI-25461,
http://linkedlifedata.com/resource/pubmed/grant/N01-AI-25462,
http://linkedlifedata.com/resource/pubmed/grant/N01-AI-25463,
http://linkedlifedata.com/resource/pubmed/grant/N01-AI-25465
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-11166898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-11425416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-15163495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-15163505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-16571878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-16641963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-16714186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-16980114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-17029131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-17412461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-17644429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-17707753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18044056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18260764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18550874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18599164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18729777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-18808338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-19453427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-606763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-606798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19773098-6353529
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-2518
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pubmed:author |
pubmed-author:CampbellJames DJD,
pubmed-author:DekkerCornelia LCL,
pubmed-author:EdwardsKathryn MKM,
pubmed-author:HillHeatherH,
pubmed-author:HoDora YDY,
pubmed-author:KeitelWendy AWA,
pubmed-author:LengLingL,
pubmed-author:MinkChrisAnnaC,
pubmed-author:NoahDiana LDL,
pubmed-author:PatelShital MSM,
pubmed-author:TalbotHelen KHK
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6642-8
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:19773098-Adjuvants, Immunologic,
pubmed-meshheading:19773098-Adolescent,
pubmed-meshheading:19773098-Adult,
pubmed-meshheading:19773098-Aluminum Hydroxide,
pubmed-meshheading:19773098-Animals,
pubmed-meshheading:19773098-Antibodies, Viral,
pubmed-meshheading:19773098-Cercopithecus aethiops,
pubmed-meshheading:19773098-Dose-Response Relationship, Immunologic,
pubmed-meshheading:19773098-Double-Blind Method,
pubmed-meshheading:19773098-Female,
pubmed-meshheading:19773098-Hemagglutination Inhibition Tests,
pubmed-meshheading:19773098-Humans,
pubmed-meshheading:19773098-Influenza, Human,
pubmed-meshheading:19773098-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:19773098-Influenza Vaccines,
pubmed-meshheading:19773098-Male,
pubmed-meshheading:19773098-Neutralization Tests,
pubmed-meshheading:19773098-Vero Cells,
pubmed-meshheading:19773098-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Safety and immunogenicity of inactivated, Vero cell culture-derived whole virus influenza A/H5N1 vaccine given alone or with aluminum hydroxide adjuvant in healthy adults.
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pubmed:affiliation |
Baylor College of Medicine Vaccine Research Center, Houston, TX 77030, USA. wkeitel@bcm.edu
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