Linked Life Data

19769301

Source:http://linkedlifedata.com/resource/pubmed/id/19769301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-9-22
pubmed:abstractText
According to psychobiological model of personality proposed by Cloninger, personality traits characterizing enhanced tendency to novel stimuli, impulsivity and sociability are influenced by dopaminergic system functioning. The present study considered both the main effect of two polymorphic loci (VNTR and 2319G>A) in dopamine transporter gene (DAT1) and the role of distinct DAT1 gene haplotypes in personality traits variation in 592 healthy individuals belonging to different ethnicities (men and women). The results of the study revealed the involvement of VNTR and 2319G>A polymorphisms in Novelty Seeking variation and the main effect of 2319G>A polymorphism on Reward Dependence (TCI) observed in Russian females. Moreover, DAT1 gene haplotype effect on Novelty Seeking in Russian females and on Persistence (TCI) in Tatar females was demonstrated. Reported in the current study results pointed to the involvement of dopaminergic system (DAT1 gene in particular) in variation of personality traits characterizing the tendency to novel stimuli, purposefulness, and sociability specifically in women.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0016-6758
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1110-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Role of dopamine transporter gene (DAT1) polymorphisms in personality traits variation].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't