Linked Life Data

19767856

Source:http://linkedlifedata.com/resource/pubmed/id/19767856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-9-21
pubmed:abstractText
Deinococcus radiodurans (ex Raj et al. 1960) Brooks and Murray 1981 is well known for its efficient repair of various types of physically or chemically induced DNA damage caused by ionizing and ultraviolet radiation or H2O2. RecG codes for a helicase that is known to be involved in repairing oxidative damage in other bacterium. In this work, we constructed a DRrecG deletion mutant and investigated its possible role in H2O2-induced damage. The results showed that the deletion of DRrecG resulted in an obvious growth defect and great decrease of radioresistance of D. radiodurans to gamma radiation and H2O2. We also defined the transcriptional profiles of the recG mutant and wild-type strain with and without treatment with H2O2. These results suggested that DRrecG is important for DNA repair during oxidative damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1480-3275
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Involvement of RecG in H2O2-induced damage repair in Deinococcus radiodurans.
pubmed:affiliation
Key Laboratory for Nuclear-Agricultural Sciences of Chinese Ministry of Agriculture and Zhejiang Province, Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029 Hangzhou, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't