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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1990-11-20
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pubmed:abstractText |
The effect on excitatory amino acid (EAA)-induced toxicity of two novel non-N-methyl-D-aspartate (non-NMDA) antagonists 2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionic acid (AMOA) and 2-amino-3-[2-(3-hydroxy-5-methyl-isoxazol-4-yl)methyl-5-methyl-3- oxoisoxazolin-4-yl]propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation of the toxicity of EAAs and a convenient screening system for potential neuroprotective activity of pharmacological agents. It was demonstrated that AMNH and AMOA abolished neurotoxicity induced by kainic acid with IC50 values of 62 +/- 10 and 120 +/- 19 microM, respectively. No effect on neuronal damage induced by NMDA or AMPA could be detected.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3042
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1821-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1976762-Animals,
pubmed-meshheading:1976762-Cells, Cultured,
pubmed-meshheading:1976762-Cerebral Cortex,
pubmed-meshheading:1976762-Glutamates,
pubmed-meshheading:1976762-Glutamic Acid,
pubmed-meshheading:1976762-Isoxazoles,
pubmed-meshheading:1976762-Kainic Acid,
pubmed-meshheading:1976762-Neurons,
pubmed-meshheading:1976762-Propionic Acids,
pubmed-meshheading:1976762-Receptors, Glutamate,
pubmed-meshheading:1976762-Receptors, Neurotransmitter
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pubmed:year |
1990
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pubmed:articleTitle |
Novel glutamate receptor antagonists selectively protect against kainic acid neurotoxicity in cultured cerebral cortex neurons.
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pubmed:affiliation |
Department of Biology, Royal Danish School of Pharmacy, Copenhagen.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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