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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-4
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pubmed:abstractText |
Osteoporosis is a common condition among elderly. Genetic mapping studies repeatedly located the distal short arms of X-chromosome as the quantitative trait loci (QTL) for BMD in mice. Fine mapping of a syntenic segment on Xp22 in a Caucasian female population suggested a moderate association between lumbar spine (LS) BMD and 2 intronic SNPs in the Pirin (PIR) gene, which encodes an iron-binding nuclear protein. This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on BMD and osteoporotic risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-2763
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pubmed:author |
pubmed-author:ChanFrank W KFW,
pubmed-author:ChanIris H SIH,
pubmed-author:ChingJasmine K LJK,
pubmed-author:HoSuzanne CSC,
pubmed-author:HuhnLL,
pubmed-author:KwokAnthony W LAW,
pubmed-author:KwokTimothyT,
pubmed-author:LeungPing ChungPC,
pubmed-author:LiaoChen DiCD,
pubmed-author:OrwollEricE,
pubmed-author:SuenEddie W CEW,
pubmed-author:TangNelson L SNL
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pubmed:copyrightInfo |
(c) 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
543-50
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pubmed:meshHeading |
pubmed-meshheading:19766747-Aged,
pubmed-meshheading:19766747-Alleles,
pubmed-meshheading:19766747-Asian Continental Ancestry Group,
pubmed-meshheading:19766747-Bone Density,
pubmed-meshheading:19766747-Carrier Proteins,
pubmed-meshheading:19766747-China,
pubmed-meshheading:19766747-Cohort Studies,
pubmed-meshheading:19766747-Female,
pubmed-meshheading:19766747-Gene Frequency,
pubmed-meshheading:19766747-Haplotypes,
pubmed-meshheading:19766747-Humans,
pubmed-meshheading:19766747-Linear Models,
pubmed-meshheading:19766747-Linkage Disequilibrium,
pubmed-meshheading:19766747-Male,
pubmed-meshheading:19766747-Nuclear Proteins,
pubmed-meshheading:19766747-Polymorphism, Single Nucleotide,
pubmed-meshheading:19766747-Sex Characteristics
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pubmed:year |
2010
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pubmed:articleTitle |
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
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pubmed:affiliation |
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. nelsontang@cuhk.edu.hk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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