Linked Life Data

19766472

Source:http://linkedlifedata.com/resource/pubmed/id/19766472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-13
pubmed:abstractText
Improvement of immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a key issue determining the clinical outcome of this widely used therapeutic approach. To this end, new strategies have been prompted by recent discoveries in immunology. In the setting of human leukocyte antigen (HLA) geno(pheno)identical HSCT, better prevention and treatment of acute and chronic graft-versus-host disease (GvHD) could significantly attenuate the thymic epithelium damage responsible for delayed and incomplete T-cell reconstitution. In a haploidentical setting, methods that would significantly accelerate neothymopoiesis in the months following injection of highly purified CD34+ cells are warranted. If these objectives could be achieved, the haploidentical procedure would become more readily available to patients affected by acquired or inherited disorders of the haematopoietic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1879-0372
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
544-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Immune reconstitution after haematopoietic stem cell transplantation: obstacles and anticipated progress.
pubmed:affiliation
Assistance Publique Hôpitaux de Paris (AP-HP), Department of Biotherapy, Hôpital Necker Enfants-Malades, Paris, France. m.cavazzana@nck.aphp.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't