Linked Life Data

19766362

Source:http://linkedlifedata.com/resource/pubmed/id/19766362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-8-23
pubmed:abstractText
Studies have reported that Id-1 (inhibitor of DNA binding, or differentiation 1) protein, helix-loop-helix (HLH) transcription factor, has important roles in the development of several carcinomas. However, the role of Id-1 protein in salivary adenoid cystic carcinoma (ACC) is not clear. The expression of Id-1 protein was assessed in formalin-fixed, paraffin-embedded surgical specimens of ACCs by immunohistochemical staining. Thirty-nine of the 54 specimens of ACC stained for Id-1expression, which was significantly more than was found in pleomorphic adenomas (4/12) and normal salivary gland tissues (1/10, p<0.05). There were also significant differences between stages I and II (7/14) and III-IV (32/40) (p<0.05). Of tumours with metastases, 31/38 stained for Id-1, which was significantly higher than among those without metastases (8/16) (p<0.05). Our results showed that Id-1 may have important roles in the development of salivary ACC. It might also be a useful therapeutic tool to help prevent salivary ACC or to inhibit its malignant progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1532-1940
pubmed:author
pubmed:copyrightInfo
Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
434-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma.
pubmed:affiliation
Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't