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rdf:type |
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lifeskim:mentions |
umls-concept:C0020474,
umls-concept:C0032105,
umls-concept:C0079904,
umls-concept:C0205217,
umls-concept:C0333348,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1151293,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1879547,
umls-concept:C2745888
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pubmed:issue |
10
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
Xanthine oxidase (XO) has been described as one of the major enzymes producing free radicals in blood. Oxidative stress and inflammatory processes have been implicated in the pathogenesis of endothelial dysfunction and the progression of atherosclerosis but until now, there is little data about the influence of vascular prooxidant systems and inflammation in familial combined hyperlipidemia (FCH). Our goal was to evaluate whether XO activity was altered in FCH and if it was related to the inflammatory process represented by NFkB, IL-6 and hsCRP, and assessing the correlation between XO activity and insulin resistance (IR).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1590-3729
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2009 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
734-9
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pubmed:meshHeading |
pubmed-meshheading:19765958-Adult,
pubmed-meshheading:19765958-Atherosclerosis,
pubmed-meshheading:19765958-Biological Markers,
pubmed-meshheading:19765958-C-Reactive Protein,
pubmed-meshheading:19765958-Endothelium, Vascular,
pubmed-meshheading:19765958-Female,
pubmed-meshheading:19765958-Free Radicals,
pubmed-meshheading:19765958-Humans,
pubmed-meshheading:19765958-Hyperlipidemia, Familial Combined,
pubmed-meshheading:19765958-Inflammation,
pubmed-meshheading:19765958-Insulin Resistance,
pubmed-meshheading:19765958-Interleukin-6,
pubmed-meshheading:19765958-Lipid Peroxidation,
pubmed-meshheading:19765958-Lipids,
pubmed-meshheading:19765958-Logistic Models,
pubmed-meshheading:19765958-Male,
pubmed-meshheading:19765958-Malondialdehyde,
pubmed-meshheading:19765958-Middle Aged,
pubmed-meshheading:19765958-Multivariate Analysis,
pubmed-meshheading:19765958-NF-kappa B,
pubmed-meshheading:19765958-Oxidative Stress,
pubmed-meshheading:19765958-Xanthine Oxidase
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pubmed:year |
2010
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pubmed:articleTitle |
Increased plasma xanthine oxidase activity is related to nuclear factor kappa beta activation and inflammatory markers in familial combined hyperlipidemia.
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pubmed:affiliation |
Service of Endocrinology and Nutrition, Hospital Clínico Universitario, Department of Medicine, University of Valencia, Valencia, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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