Source:http://linkedlifedata.com/resource/pubmed/id/19765801
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2009-11-16
|
| pubmed:abstractText |
YKL-40 is a growth factor for connective tissue cells and a migration factor for endothelial cells. Elevated serum level of YKL-40 has been associated with poor prognosis in many cancers. However, the status of YKL-40 expression and its clinical/prognostic significance in gastric cancer are unclear. In this study, the expression of YKL-40 was studied by immunohistochemistry in gastric cancer tissue microarray containing 172 primary gastric cancer cases and 70 adjacent nonneoplastic mucosa specimens. The correlations between YKL-40 expression and clinicopathologic features, as well as activation of PI3K/Akt pathways were addressed. Expression of YKL-40 was significantly higher in gastric cancer tissues than that in adjacent nonneoplastic tissues. Overexpression YKL-40 was found in 28.4% of gastric cancers and was significantly associated with tumor invasion (P = .007) and lymph node metastasis (P = .009). For survival study, overexpression of YKL-40 was significantly associated with worse outcome (P = .001). When known clinical variables were added to a multivariate analysis, TNM stage, tumor size, and overexpression of YKL-40 emerged as independent prognostic factors. Further study indicated that the oncogenic function of YKL-40 might be through the activation of Akt pathway. These results suggest that overexpression of YKL-40 is correlated with the aggressive behavior of tumor cells, which could be used as an independent molecular marker for the predicting poor prognosis of patients with gastric cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/CHI3L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1532-8392
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| pubmed:author |
pubmed-author:BiJiongJ,
pubmed-author:GuanXin-YuanXY,
pubmed-author:HeYu-longYL,
pubmed-author:LaiYing-RongYR,
pubmed-author:LauSze-HangSH,
pubmed-author:LvZi-LiZL,
pubmed-author:RITA,
pubmed-author:TURJ JJJ,
pubmed-author:WenJian-MingJM,
pubmed-author:WuHui-qunHQ,
pubmed-author:YdeGG,
pubmed-author:ZhanWen-HuaWH,
pubmed-author:ZhongJue-MinJM
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1790-7
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:19765801-Adipokines,
pubmed-meshheading:19765801-Adult,
pubmed-meshheading:19765801-Aged,
pubmed-meshheading:19765801-Aged, 80 and over,
pubmed-meshheading:19765801-Female,
pubmed-meshheading:19765801-Glycoproteins,
pubmed-meshheading:19765801-Humans,
pubmed-meshheading:19765801-Immunohistochemistry,
pubmed-meshheading:19765801-Kaplan-Meier Estimate,
pubmed-meshheading:19765801-Lectins,
pubmed-meshheading:19765801-Male,
pubmed-meshheading:19765801-Middle Aged,
pubmed-meshheading:19765801-Neoplasm Staging,
pubmed-meshheading:19765801-Prognosis,
pubmed-meshheading:19765801-Stomach Neoplasms,
pubmed-meshheading:19765801-Tissue Array Analysis,
pubmed-meshheading:19765801-Tumor Markers, Biological,
pubmed-meshheading:19765801-Up-Regulation,
pubmed-meshheading:19765801-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Overexpression of YKL-40 is an independent prognostic marker in gastric cancer.
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| pubmed:affiliation |
Laboratory of Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|