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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
2009-9-18
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pubmed:abstractText |
To clarify the underlying mechanisms of L-DOPA induced vasoconstriction in rat aorta. Methods: The effect of L-DOPA on phenylephrine-induced contractile force of blood vessels was examined in vitro using rat aortic ring preparations by isometric tension experiment. Involvement of nitric oxide (NO) in the effect of L-DOPA on vascular smooth muscle was studied by using N(omega)-Nitro-L-arginine (L-NNA), Sodium nitroprusside (SNP) in endothelium-intact and endothelium-denuded aortic rings.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1349-6867
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
120-9
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pubmed:meshHeading |
pubmed-meshheading:19763024-Animals,
pubmed-meshheading:19763024-Aorta, Thoracic,
pubmed-meshheading:19763024-Cells, Cultured,
pubmed-meshheading:19763024-Cyclic GMP,
pubmed-meshheading:19763024-Drug Synergism,
pubmed-meshheading:19763024-Endothelium, Vascular,
pubmed-meshheading:19763024-Guanylate Cyclase,
pubmed-meshheading:19763024-Levodopa,
pubmed-meshheading:19763024-Male,
pubmed-meshheading:19763024-Myocytes, Smooth Muscle,
pubmed-meshheading:19763024-Nitric Oxide,
pubmed-meshheading:19763024-Phenylephrine,
pubmed-meshheading:19763024-Rats,
pubmed-meshheading:19763024-Rats, Wistar,
pubmed-meshheading:19763024-Reactive Oxygen Species,
pubmed-meshheading:19763024-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:19763024-Vasodilation
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pubmed:year |
2009
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pubmed:articleTitle |
L-DOPA inhibits nitric oxide-dependent vasorelaxation via production of reactive oxygen species in rat aorta.
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pubmed:affiliation |
Department of Anesthesiology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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