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rdf:type |
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lifeskim:mentions |
umls-concept:C0001455,
umls-concept:C0006772,
umls-concept:C0007610,
umls-concept:C0007634,
umls-concept:C0022180,
umls-concept:C0031715,
umls-concept:C0040715,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0871261,
umls-concept:C1522702,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
2009-9-18
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pubmed:abstractText |
Calmodulin (CaM) activation by Ca(2+), its translocation to the nucleus, and stimulation of phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB) (P-CREB) are necessary for new gene expression and have been linked to long-term potentiation, a process important in memory formation. Because isoflurane affects memory, we tested whether isoflurane interfered with the translocation of CaM to the neuronal cell nucleus and attenuated the formation P-CREB.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Pyridinecarboxylic acid...,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/CREB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, L-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrendipine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1127-34
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pubmed:meshHeading |
pubmed-meshheading:19762740-3-Pyridinecarboxylic acid...,
pubmed-meshheading:19762740-Active Transport, Cell Nucleus,
pubmed-meshheading:19762740-Anesthetics, Inhalation,
pubmed-meshheading:19762740-Calcium,
pubmed-meshheading:19762740-Calcium Channel Agonists,
pubmed-meshheading:19762740-Calcium Channel Blockers,
pubmed-meshheading:19762740-Calcium Channels, L-Type,
pubmed-meshheading:19762740-Calmodulin,
pubmed-meshheading:19762740-Cell Line, Tumor,
pubmed-meshheading:19762740-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:19762740-Dose-Response Relationship, Drug,
pubmed-meshheading:19762740-Down-Regulation,
pubmed-meshheading:19762740-Humans,
pubmed-meshheading:19762740-Isoflurane,
pubmed-meshheading:19762740-Membrane Potentials,
pubmed-meshheading:19762740-Neuroblastoma,
pubmed-meshheading:19762740-Neurons,
pubmed-meshheading:19762740-Nitrendipine,
pubmed-meshheading:19762740-Phosphorylation,
pubmed-meshheading:19762740-Potassium Chloride,
pubmed-meshheading:19762740-Time Factors,
pubmed-meshheading:19762740-omega-Conotoxin GVIA
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pubmed:year |
2009
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pubmed:articleTitle |
Isoflurane inhibits cyclic adenosine monophosphate response element-binding protein phosphorylation and calmodulin translocation to the nucleus of SH-SY5Y cells.
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pubmed:affiliation |
Department of Anesthesiology, NYU School of Medicine, 550 1st Ave., New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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