| pubmed-article:19762485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0162597 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0376152 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0013203 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C1516048 | lld:lifeskim |
| pubmed-article:19762485 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:19762485 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:19762485 | pubmed:dateCreated | 2009-12-7 | lld:pubmed |
| pubmed-article:19762485 | pubmed:abstractText | Marrow stromal cells (MSCs) provide important survival and drug resistance signals to chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL-MSC interactions are heterogeneous. Therefore, we tested different human and murine MSC lines and primary human MSCs for their ability to protect CLL cells from spontaneous and drug-induced apoptosis. Our results show that both human and murine MSCs are equally effective in protecting CLL cells from fludarabine-induced apoptosis. This protective effect was sustained over a wide range of CLL-MSC ratios (5:1 to 100:1), and the levels of protection were reproducible in 4 different laboratories. Human and murine MSCs also protected CLL cells from dexamethasone- and cyclophosphamide-induced apoptosis. This protection required cell-cell contact and was virtually absent when CLL cells were separated from the MSCs by micropore filters. Furthermore, MSCs maintained Mcl-1 and protected CLL cells from spontaneous and fludarabine-induced Mcl-1 and PARP cleavage. Collectively, these studies define common denominators for CLL cocultures with MSCs. They also provide a reliable, validated tool for future investigations into the mechanism of MSC-CLL cross talk and for drug testing in a more relevant fashion than the commonly used suspension cultures. | lld:pubmed |
| pubmed-article:19762485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19762485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762485 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19762485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19762485 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19762485 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:EstrovZeevZ | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:ChenRongR | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:GandhiVarshaV | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:PlunkettWilli... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:KeatingMichae... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:BurgerJan AJA | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:DingWeiW | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:KayNeil ENE | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:ShehataMedhat... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:JägerUlrichU | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:WierdaWilliam... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:BalakrishnanK... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:SivinaMariela... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:QuirogaMaite... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:KurtovaAntoni... | lld:pubmed |
| pubmed-article:19762485 | pubmed:author | pubmed-author:SchnablSusann... | lld:pubmed |
| pubmed-article:19762485 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19762485 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:19762485 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19762485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19762485 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19762485 | pubmed:pagination | 4441-50 | lld:pubmed |
| pubmed-article:19762485 | pubmed:meshHeading | pubmed-meshheading:19762485... | lld:pubmed |
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| pubmed-article:19762485 | pubmed:meshHeading | pubmed-meshheading:19762485... | lld:pubmed |
| pubmed-article:19762485 | pubmed:meshHeading | pubmed-meshheading:19762485... | lld:pubmed |
| pubmed-article:19762485 | pubmed:meshHeading | pubmed-meshheading:19762485... | lld:pubmed |
| pubmed-article:19762485 | pubmed:meshHeading | pubmed-meshheading:19762485... | lld:pubmed |
| pubmed-article:19762485 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19762485 | pubmed:articleTitle | Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. | lld:pubmed |
| pubmed-article:19762485 | pubmed:affiliation | Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230-1402, USA. | lld:pubmed |
| pubmed-article:19762485 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19762485 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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