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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-10-15
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pubmed:abstractText |
Unsatisfactory efficacy of current treatments for advanced lung cancer has prompted the search for new therapies, with sorafenib, a multikinase inhibitor, being one candidate drug. This phase I trial was conducted to evaluate drug safety and pharmacokinetics as well as tumor response of sorafenib in combination with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer (NSCLC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1573-0646
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pubmed:author |
pubmed-author:FukinoKoichiK,
pubmed-author:FukuokaMasahiroM,
pubmed-author:HasegawaYoshikazuY,
pubmed-author:KanedaHiroyasuH,
pubmed-author:KawadaAkiraA,
pubmed-author:MiyazakiMasakiM,
pubmed-author:MorinagaRyotaroR,
pubmed-author:NakagawaKazuhikoK,
pubmed-author:OkamotoIsamuI,
pubmed-author:SatohTarohT,
pubmed-author:TanigawaTakahikoT,
pubmed-author:UedaShinyaS
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
844-53
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pubmed:meshHeading |
pubmed-meshheading:19760364-Adult,
pubmed-meshheading:19760364-Aged,
pubmed-meshheading:19760364-Antineoplastic Agents,
pubmed-meshheading:19760364-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19760364-Benzenesulfonates,
pubmed-meshheading:19760364-Carboplatin,
pubmed-meshheading:19760364-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19760364-Demography,
pubmed-meshheading:19760364-Dose-Response Relationship, Drug,
pubmed-meshheading:19760364-Female,
pubmed-meshheading:19760364-Humans,
pubmed-meshheading:19760364-Lung Neoplasms,
pubmed-meshheading:19760364-Male,
pubmed-meshheading:19760364-Middle Aged,
pubmed-meshheading:19760364-Neoplasm Staging,
pubmed-meshheading:19760364-Paclitaxel,
pubmed-meshheading:19760364-Pyridines,
pubmed-meshheading:19760364-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.
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pubmed:affiliation |
Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan. chi-okamoto@dotd.med.kindai.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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