Source:http://linkedlifedata.com/resource/pubmed/id/19759041
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-10-13
|
| pubmed:abstractText |
To compare the antibacterial effects (ABEs) of the free (f) drugs daptomycin, vancomycin and teicoplanin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), using high and low inocula in a pharmacokinetic in vitro model. To determine the daptomycin fAUC/MIC ratio for a static effect and 3 log reduction in viable count and relate this target to the clinical breakpoint.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1460-2091
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1044-51
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| pubmed:meshHeading |
pubmed-meshheading:19759041-Anti-Bacterial Agents,
pubmed-meshheading:19759041-Daptomycin,
pubmed-meshheading:19759041-Humans,
pubmed-meshheading:19759041-Methicillin-Resistant Staphylococcus aureus,
pubmed-meshheading:19759041-Microbial Sensitivity Tests,
pubmed-meshheading:19759041-Microbial Viability,
pubmed-meshheading:19759041-Models, Theoretical,
pubmed-meshheading:19759041-Staphylococcal Infections,
pubmed-meshheading:19759041-Teicoplanin,
pubmed-meshheading:19759041-Vancomycin,
pubmed-meshheading:19759041-Vancomycin Resistance
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Comparative antibacterial effects of daptomycin, vancomycin and teicoplanin studied in an in vitro pharmacokinetic model of infection.
|
| pubmed:affiliation |
Bristol Centre for Antimicrobial Research and Evaluation, Department of Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK. karen.bowker@nbt.nhs.uk
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|