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rdf:type |
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lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0020861,
umls-concept:C0023823,
umls-concept:C0205296,
umls-concept:C0205349,
umls-concept:C0439858,
umls-concept:C0443177,
umls-concept:C0871261,
umls-concept:C1517004,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2754997,
umls-concept:C2911692
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pubmed:dateCreated |
2009-9-17
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pubmed:abstractText |
It is hypothesized that IgM antibodies to oxidized LDL are anti-atherogenic. Myeloperoxidase from plaque-infiltrating neutrophils catalyzes the production of hypochlorite (HOCl), which oxidizes LDL. Here we study the IgM response to HOCl-modified LDL in comparison to titers of T15 clonotypic natural antibodies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1749-6632
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
1173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-9
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pubmed:meshHeading |
pubmed-meshheading:19758162-Animals,
pubmed-meshheading:19758162-Atherosclerosis,
pubmed-meshheading:19758162-Cholesterol,
pubmed-meshheading:19758162-Dietary Fats,
pubmed-meshheading:19758162-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19758162-Female,
pubmed-meshheading:19758162-Humans,
pubmed-meshheading:19758162-Hypochlorous Acid,
pubmed-meshheading:19758162-Immunoglobulin M,
pubmed-meshheading:19758162-Lipoproteins, LDL,
pubmed-meshheading:19758162-Mice,
pubmed-meshheading:19758162-Mice, Inbred C57BL,
pubmed-meshheading:19758162-Mice, Knockout,
pubmed-meshheading:19758162-Oxidation-Reduction,
pubmed-meshheading:19758162-Receptors, LDL
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pubmed:year |
2009
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pubmed:articleTitle |
The IgM response to modified LDL in experimental atherosclerosis: hypochlorite-modified LDL IgM antibodies versus classical natural T15 IgM antibodies.
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pubmed:affiliation |
Internal Medicine, Clinical and Experimental Immunology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
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pubmed:publicationType |
Journal Article
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