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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
The ability to deliver plasmid DNA (pDNA) to specific cells in vivo is crucial for achieving efficient targeted transfection with nonviral vectors. We previously used stealth liposomes containing the chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA(3)-DTDA) to target delivery of antigen and cytokines to immune cells in vivo. In the present study, we utilized liposomes containing NTA(3)-DTDA and the ionizable aminolipid 1,2-dioleoyl-3-dimethyl-ammonium-propane (DODAP) to incorporate pDNA into complexes for targeting to cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1521-2254
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1048-63
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pubmed:meshHeading |
pubmed-meshheading:19757485-Cells, Cultured,
pubmed-meshheading:19757485-Chelating Agents,
pubmed-meshheading:19757485-DNA,
pubmed-meshheading:19757485-Gene Therapy,
pubmed-meshheading:19757485-Genetic Vectors,
pubmed-meshheading:19757485-Green Fluorescent Proteins,
pubmed-meshheading:19757485-Humans,
pubmed-meshheading:19757485-Lipids,
pubmed-meshheading:19757485-Liposomes,
pubmed-meshheading:19757485-Particle Size,
pubmed-meshheading:19757485-Plasmids,
pubmed-meshheading:19757485-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Targeting of plasmid DNA-lipoplexes to cells with molecules anchored via a metal chelator lipid.
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pubmed:affiliation |
Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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