Linked Life Data

1975724

Source:http://linkedlifedata.com/resource/pubmed/id/1975724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-10-10
pubmed:abstractText
The influence of different interferons (IFNs) on HBsAg production and DNA synthesis was studied in PLC/PRF/5 cells using 30 I.U./ml of natural HuIFN-alpha, 25 I.U./ml of recombinant HuIFN-alpha 2, and 5 I.U./ml of natural murine IFN-alpha/beta. All three IFN types inhibited significant inhibitory effect on HBsAg production during the second 24 hr-interval following their addition. After 96 hr HBsAg production had returned to normal levels. Natural HuIFN-alpha clearly depressed cellular DNA synthesis 24 hr after IFN addition which returned to normal within the next 24 hr. Recombinant HuIFN-alpha 2 influenced DNA synthesis only slightly and the mouse IFN-alpha/beta showed no effect.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0001-723X
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
44-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Relationship between depression of HBsAg production and DNA synthesis by interferons in human hepatoma cell line.
pubmed:affiliation
Research Institute of Preventive Medicine, Slovak Academy of Sciences, Bratislava.
pubmed:publicationType
Journal Article