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rdf:type |
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lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0069717,
umls-concept:C0215848,
umls-concept:C0242184,
umls-concept:C0334227,
umls-concept:C0524899,
umls-concept:C0683598,
umls-concept:C1527249,
umls-concept:C1822686,
umls-concept:C1880177,
umls-concept:C2348110,
umls-concept:C2348977
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pubmed:issue |
8
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pubmed:dateCreated |
2009-10-14
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pubmed:abstractText |
Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to investigate the relative contribution of HIF-1 (hypoxia-inducible factor-1)-mediated gene expression and drug penetrance to oxaliplatin resistance using three-dimensional spheroids.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1532-1827
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pubmed:author |
pubmed-author:BarathovaMM,
pubmed-author:Brittain-DissontSS,
pubmed-author:CowenR LRL,
pubmed-author:EustaceA JAJ,
pubmed-author:FryeG HGH,
pubmed-author:OttleyC JCJ,
pubmed-author:PearsonD GDG,
pubmed-author:RobertsD LDL,
pubmed-author:StratfordI JIJ,
pubmed-author:TilbyM JMJ,
pubmed-author:WilliamsK JKJ
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1290-7
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pubmed:dateRevised |
2010-10-21
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pubmed:meshHeading |
pubmed-meshheading:19755992-Antineoplastic Agents,
pubmed-meshheading:19755992-Cell Hypoxia,
pubmed-meshheading:19755992-Cell Survival,
pubmed-meshheading:19755992-Colorectal Neoplasms,
pubmed-meshheading:19755992-Drug Resistance, Neoplasm,
pubmed-meshheading:19755992-HCT116 Cells,
pubmed-meshheading:19755992-Humans,
pubmed-meshheading:19755992-Hypoxia-Inducible Factor 1,
pubmed-meshheading:19755992-Organoplatinum Compounds,
pubmed-meshheading:19755992-Spheroids, Cellular
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pubmed:year |
2009
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pubmed:articleTitle |
Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.
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pubmed:affiliation |
Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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