Linked Life Data

19751774

Source:http://linkedlifedata.com/resource/pubmed/id/19751774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-20
pubmed:abstractText
Signal transducer and activator of transcription 3 (STAT3) acts as a mediator and biomarker in endothelial activation. We have recently shown that a novel adipokine visfatin promotes endothelial angiogenesis. The present study was to determine whether visfatin affects STAT3 activity and to explore the potential target gene(s). Here, we found that visfatin induced the activation of STAT3, as characterized by increased tyrosine phosphorylation, nuclear translocation, and DNA-binding activity in human endothelial cells. In addition, visfatin significantly upregulated mRNA and protein levels of endothelial interleukin-6 (IL-6), which was blocked by a specific inhibitor of STAT3 signaling and by the transfection of siRNA specific for STAT3. Furthermore, visfatin-induced angiogenesis was reduced by the inhibition of STAT3 signaling or neutralization of IL-6 function, as measured by tube formation, rat aortic ring assay, and mouse Matrigel plug assay. Taken together, our results provide the first example of STAT3-dependent endothelial IL-6 induction by visfatin and of the role of IL-6 in mediating visfatin-induced angiogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1793
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1759-67
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis.
pubmed:affiliation
Department of Physiology, School of Medicine, Yangsan Campus of Pusan National University, Yangsan, 626-870, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't