Linked Life Data

19751207

Source:http://linkedlifedata.com/resource/pubmed/id/19751207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
34
pubmed:dateCreated
2010-1-4
pubmed:abstractText
Neurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia, and others are multi-factorial illnesses, in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. Thus, presently there are no effective cures for these diseases. Some phenotypic as well as mechanistic features, common to the most of NDs, can be linked to epigenetic defects, that can lead to alteration of acetylation homeostasis and impairment of the histone acetyltransferase (HAT): histone deacetylase (HDAC) balance. Here we survey most of the recent applications of HDAC inhibitors in the cited NDs, and we make the point of our (up to now) knowledge about the involvement of singular HDAC/SIRT isoform in NDs and other CNS pathologies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1873-4286
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3940-57
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.
pubmed:affiliation
Pasteur Institute, Cenci-Bolognetti Foundation, Department of Drug Chemistry and Technologies, University of Rome "La Sapienza", P. le A. Moro 5, 00185 Rome, Italy. antonello.mai@uniroma1.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't