Source:http://linkedlifedata.com/resource/pubmed/id/19749740
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2009-11-30
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| pubmed:abstractText |
Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. We and others showed that CRTC1-MAML2 gene fusion was associated with favorable clinicopathological tumor features. Recently, a novel gene fusion, CRTC3-MAML2, was reported as a rare gene alteration in a case of mucoepidermoid carcinoma. However, its frequency and clinicopathological significance remains unclear. In all, 101 cases of mucoepidermoid carcinoma and 89 cases of non-mucoepidermoid carcinoma of the salivary gland were analyzed, and RNA was extracted from formalin-fixed, paraffin-embedded specimens. In the CRTC family, there have been three genes, CRTC1, CRTC2, and CRTC3. We developed reverse transcription-polymerase chain reaction (RT-PCR) assays for CRTC1-MAML2, CRTC2-MAML2, and CRTC3-MAML2 fusions. Clinicopathological data of the patients were obtained from their clinical records. Of 101 cases of mucoepidermoid carcinoma, 34 (34%) and 6 (6%) were positive for CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts. However, in the 89 cases of non-mucoepidermoid carcinoma, neither transcript was noted. In the former cases, CRTC1-MAML2 and CRTC3-MAML2 fusions were mutually exclusive. The other fusion, CRTC2-MAML2, was not detected. We confirmed that the clinicopathological features of CRTC1-MAML2-positive mucoepidermoid carcinomas indicated an indolent course. CRTC3-MAML2-positive mucoepidermoid carcinomas also had clinicopathologically favorable features; all cases showed a less advanced clinical stage, negative nodal metastasis, no high-grade tumor histology, and no recurrence or tumor-related death after surgical resection of the tumor. It is interesting to note that patients with CRTC3-MAML2-positive tumors (mean 36 years of age) were significantly younger that those with the CRTC1-MAML2 fusion (55 years) and those with fusion-negative tumors (58 years). In conclusion, CRTC3-MAML2 fusion, which is mutually exclusive with CRTC1-MAML2 fusion and specific to mucoepidermoid carcinoma, may be detected more frequently than previously expected. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CRTC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CRTC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CRTC3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MAML2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1530-0285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1575-81
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:19749740-Adult,
pubmed-meshheading:19749740-Age Factors,
pubmed-meshheading:19749740-Carcinoma, Mucoepidermoid,
pubmed-meshheading:19749740-DNA-Binding Proteins,
pubmed-meshheading:19749740-Disease-Free Survival,
pubmed-meshheading:19749740-Female,
pubmed-meshheading:19749740-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19749740-Gene Fusion,
pubmed-meshheading:19749740-Humans,
pubmed-meshheading:19749740-Kaplan-Meier Estimate,
pubmed-meshheading:19749740-Male,
pubmed-meshheading:19749740-Middle Aged,
pubmed-meshheading:19749740-Neoplasm Staging,
pubmed-meshheading:19749740-Nuclear Proteins,
pubmed-meshheading:19749740-RNA, Messenger,
pubmed-meshheading:19749740-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19749740-Salivary Gland Neoplasms,
pubmed-meshheading:19749740-Time Factors,
pubmed-meshheading:19749740-Transcription Factors,
pubmed-meshheading:19749740-Treatment Outcome,
pubmed-meshheading:19749740-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.
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| pubmed:affiliation |
Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
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| pubmed:publicationType |
Journal Article
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