Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8.
Department of Research and Development, Anti-Aging Science, Co Ltd, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.