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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-22
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pubmed:abstractText |
Obesity has been strongly associated with the development and aggravation of hypertension and chronic kidney disease. To date, the systemic renin-angiotensin system (RAS) has been known to involve in obesity-induced tissue damage and hypertension. However, the intrarenal mechanism whereby obesity induces and aggravates hypertension and renal disease remains poorly understood. Therefore, we investigated the role of intrarenal RAS and oxidative stress in diet-induced hypertension and renal inflammation in spontaneously hypertensive rats (SHR) fed a high-fat diet.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2385
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pubmed:author |
pubmed-author:ChangYoon SikYS,
pubmed-author:ChungHyun WhaHW,
pubmed-author:ChungSungjinS,
pubmed-author:KimByung SooBS,
pubmed-author:KimGheun-HoGH,
pubmed-author:KimHyung WookHW,
pubmed-author:LeeJeong-HwaJH,
pubmed-author:LimJi HeeJH,
pubmed-author:ParkCheol WheeCW,
pubmed-author:ShinSeok JoonSJ,
pubmed-author:YounDong-YeDY
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-99
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pubmed:meshHeading |
pubmed-meshheading:19749146-Animals,
pubmed-meshheading:19749146-Antihypertensive Agents,
pubmed-meshheading:19749146-Antioxidants,
pubmed-meshheading:19749146-Benzimidazoles,
pubmed-meshheading:19749146-Cyclic N-Oxides,
pubmed-meshheading:19749146-Dietary Fats,
pubmed-meshheading:19749146-Hypertension,
pubmed-meshheading:19749146-Kidney Diseases,
pubmed-meshheading:19749146-Male,
pubmed-meshheading:19749146-Obesity,
pubmed-meshheading:19749146-Oxidative Stress,
pubmed-meshheading:19749146-Rats,
pubmed-meshheading:19749146-Rats, Inbred SHR,
pubmed-meshheading:19749146-Rats, Wistar,
pubmed-meshheading:19749146-Spin Labels,
pubmed-meshheading:19749146-Tetrazoles
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pubmed:year |
2010
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pubmed:articleTitle |
Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats.
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pubmed:affiliation |
Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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