Linked Life Data

19749098

Source:http://linkedlifedata.com/resource/pubmed/id/19749098

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2009-9-14
pubmed:abstractText
Young birds, in their post-natal growth period, may reduce their growth and metabolism when facing a food shortage. To examine how such responses can be mediated by endocrine-related factors, we exposed Japanese quail chicks to food restriction for either 2 days (age 6-8 days) or 5 days (age 6-11 days). We then measured growth and resting metabolic rate (RMR), and circulating 3,3',5-triiodo-l-thyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) levels as well as expression patterns of genes involved in growth (insulin-like growth factor-I: IGF-I) and thyroid hormone signalling (thyroid-stimulating hormone-beta: TSHbeta, type II iodothyronine deiodinase: D2, thyroid hormone receptors isoforms: TRalpha and TRbeta). The food-restricted chicks receiving a weight-maintenance diet showed reductions in structural growth and RMR. Plasma levels of both T3 and T4 were reduced in the food-restricted birds, and within the 5 days food-restricted group there was a positive correlation between RMR and T3. IGF-I mRNA showed significantly higher abundance in the liver of ad libitum fed birds at day 8 compared with food-restricted birds. In the brain, TSHbeta mRNA level tended to be lower in food-restricted quails on day 8 compared with controls. Furthermore, TRalpha expression was lower in the brain of food-restricted birds at day 8 compared with birds fed ad libitum. Interestingly, brain D2 mRNA was negatively correlated with plasma T3 levels, tending to increase with the length of food restriction. Overall, our results show that food restriction produced significant effects on circulating thyroid hormones and differentially affected mRNA species in the thyroid hormone signalling pathway. Thus, we conclude that the effects of food restriction observed on growth and metabolism were partly mediated by changes in the endocrine-related factors investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1477-9145
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
212
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3060-7
pubmed:meshHeading
pubmed-meshheading:19749098-Animals, pubmed-meshheading:19749098-Basal Metabolism, pubmed-meshheading:19749098-Body Size, pubmed-meshheading:19749098-Brain, pubmed-meshheading:19749098-Coturnix, pubmed-meshheading:19749098-Eating, pubmed-meshheading:19749098-Insulin-Like Growth Factor I, pubmed-meshheading:19749098-Iodide Peroxidase, pubmed-meshheading:19749098-Kidney, pubmed-meshheading:19749098-Liver, pubmed-meshheading:19749098-Organ Size, pubmed-meshheading:19749098-RNA, Messenger, pubmed-meshheading:19749098-Signal Transduction, pubmed-meshheading:19749098-Thyroid Gland, pubmed-meshheading:19749098-Thyroid Hormone Receptors alpha, pubmed-meshheading:19749098-Thyroid Hormone Receptors beta, pubmed-meshheading:19749098-Thyrotropin, beta Subunit, pubmed-meshheading:19749098-Thyroxine, pubmed-meshheading:19749098-Triiodothyronine, Reverse
pubmed:year
2009
pubmed:articleTitle
Food restriction in young Japanese quails: effects on growth, metabolism, plasma thyroid hormones and mRNA species in the thyroid hormone signalling pathway.
pubmed:affiliation
Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. bernt.ronning@bio.ntnu.no
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't