Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1990-9-27
|
pubmed:abstractText |
The genes encoding apolipoproteins AI, CIII, and AIV, three plasma proteins involved in lipid metabolism, are clustered within a 15-kb DNA segment (apoAI-CIII-AIV gene cluster) located on human chromosome 11 at band q23. The gene encoding the neural cell adhesion molecule (NCAM), a cell surface glycoprotein involved in cell-cell recognition during morphogenesis, is also located on chromosome 11, band q23. In this report, 12 previously described restriction fragment length polymorphisms (RFLPs) in the apoAI-CIII-AIV gene cluster were tested for cosegregation with a newly identified BamHI RFLP in the NCAM gene using 13 families. The results show that the apoAI-CIII-AIV gene cluster and the NCAM gene loci are linked with a maximum lod score of 15.9 at a recombination fraction of 0.028. In addition, an approach for the most efficient use of the apoAI-CIII-AIV gene cluster polymorphisms, based on the evaluation of their individual and cumulative heterozygosities, is presented.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein C-III,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins C,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/apolipoprotein A-IV
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0888-7543
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
633-7
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:1974882-Apolipoprotein A-I,
pubmed-meshheading:1974882-Apolipoprotein C-III,
pubmed-meshheading:1974882-Apolipoproteins A,
pubmed-meshheading:1974882-Apolipoproteins C,
pubmed-meshheading:1974882-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:1974882-Chromosomes, Human, Pair 11,
pubmed-meshheading:1974882-Female,
pubmed-meshheading:1974882-Genes,
pubmed-meshheading:1974882-Genetic Linkage,
pubmed-meshheading:1974882-Humans,
pubmed-meshheading:1974882-Lod Score,
pubmed-meshheading:1974882-Male,
pubmed-meshheading:1974882-Multigene Family,
pubmed-meshheading:1974882-Pedigree,
pubmed-meshheading:1974882-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1974882-Restriction Mapping
|
pubmed:year |
1990
|
pubmed:articleTitle |
Genetic linkage of the human apolipoprotein AI-CIII-AIV gene cluster and the neural cell adhesion molecule (NCAM) gene.
|
pubmed:affiliation |
Department of Cardiology, Children's Hospital, Boston, Massachusetts.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|