Linked Life Data

19748709

Source:http://linkedlifedata.com/resource/pubmed/id/19748709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-25
pubmed:abstractText
A series of oligomeric formylpeptides were synthesized by cross-linking the prototype fMLP using a Lys residue. They were then investigated for their ability to stimulate chemotaxis, superoxide anion production, and lytic enzyme release in human neutrophils. Although active in stimulating the different receptor isoforms, leading to the different biological responses, these analogues showed a lesser potency and affinity than the standard peptide. On the basis of the results reported here, we can hypothesise that: (i) the increased bulk of these molecules seems to hinder their correct positioning into the receptor pocket, thereby hindering favourable receptor interaction; and that: (ii) fMLP space positions do not seem to allow the ligand to increase biological responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1768-3254
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4926-30
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Oligomeric formylpeptide activity on human neutrophils.
pubmed:affiliation
Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17/19, Ferrara 44100, Italy. g5z@unife.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't