| pubmed-article:1974863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1974863 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1974863 | lifeskim:mentions | umls-concept:C0043162 | lld:lifeskim |
| pubmed-article:1974863 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:1974863 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1974863 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:1974863 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1974863 | pubmed:dateCreated | 1990-9-21 | lld:pubmed |
| pubmed-article:1974863 | pubmed:abstractText | We have examined the importance of L3T4+ (murine equivalent to CD4+) cells for hematopoietic regulation in vivo in unperturbed mice and mice recovering from total-body irradiation (TBI) using a cytotoxic monoclonal antibody (MoAb) raised with the GK 1.5 hybridoma. Ablating L3T4+ cells in "normal" (unperturbed) B6D2F1 mice substantially decreased the S-phase fraction (determined by in vivo hydroxyurea suicide) of erythroid progenitor cells (erythroid colony-forming units, CFU-E) as compared to the pretreatment level (10% +/- 14.1% [day 3 following depletion] vs 79.8% +/- 15.9%, respectively) with a corresponding decrease in the marrow content of CFU-E at this time to approximately 1% of the pretreatment value. Although the S-phase fraction of CFU-GM was decreased to 2.2% +/- 3.1% 3 days after L3T4+ cell ablation from the 21.3% +/- 8.3% pretreatment value, CFU-GM cellularity showed little change over the 3 days following anti-L3T4 treatment. Anti-L3T4 MoAb treatment had little or no effect on either the S-phase fraction or the marrow content of hematopoietic "stem cells" (spleen colony-forming units, CFU-S) committed to myeloerythroid differentiation. Ablating L3T4+ cells prior to a single dose of 2 Gy TBI resulted in significantly reduced marrow contents of CFU-S on day 3 and granulocyte-macrophage colony-forming units (CFU-GM) on day 6 following TBI, with little or no effect on the corresponding recovery of CFU-E. The present findings provide the first in vivo evidence that L3T4+ cells are involved in: 1) maintaining the proliferative activity of CFU-E and CFU-GM in unperturbed mice and 2) supporting the restoration of CFU-S and CFU-GM following TBI-induced myelosuppression. | lld:pubmed |
| pubmed-article:1974863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1974863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1974863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1974863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1974863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1974863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1974863 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1974863 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:1974863 | pubmed:author | pubmed-author:NakeffAA | lld:pubmed |
| pubmed-article:1974863 | pubmed:author | pubmed-author:PantelKK | lld:pubmed |
| pubmed-article:1974863 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1974863 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:1974863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1974863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1974863 | pubmed:pagination | 863-7 | lld:pubmed |
| pubmed-article:1974863 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1974863 | pubmed:meshHeading | pubmed-meshheading:1974863-... | lld:pubmed |
| pubmed-article:1974863 | pubmed:meshHeading | pubmed-meshheading:1974863-... | lld:pubmed |
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| pubmed-article:1974863 | pubmed:meshHeading | pubmed-meshheading:1974863-... | lld:pubmed |
| pubmed-article:1974863 | pubmed:meshHeading | pubmed-meshheading:1974863-... | lld:pubmed |
| pubmed-article:1974863 | pubmed:meshHeading | pubmed-meshheading:1974863-... | lld:pubmed |
| pubmed-article:1974863 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1974863 | pubmed:articleTitle | Differential effect of L3T4+ cells on recovery from total-body irradiation. | lld:pubmed |
| pubmed-article:1974863 | pubmed:affiliation | Wayne State University School of Medicine, Department of Internal Medicine, Detroit, MI 48201. | lld:pubmed |
| pubmed-article:1974863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1974863 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1974863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
