Linked Life Data

1974828

Source:http://linkedlifedata.com/resource/pubmed/id/1974828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-9-27
pubmed:abstractText
The meeting offered ample evidence that the field of poxvirology has truly come of age. Many investigators were attracted to the field by its experimental feasibility; indeed, the virions are "in vitro transcription systems" and the genome is a "cDNA library." The viral life cycle is synchronous and rapid and can be studied genetically and biochemically in a wide range of cell types. What has become clear is that the virus also offers a unique opportunity to dissect a range of biological problems. The enzymes involved in nucleic acid metabolism are numerous and easily accessible to study; vaccinia is fast evolving into a model system of choice for structure-function studies. The cascade of gene expression offers a chance to investigate in detail the mechanism of trans-acting factors that determine transcriptional specificity, as well as a system to probe the role of genome "chromatin" in dictating the accessibility of transcriptional units. But perhaps the most lasting impression of vaccinia is as a virus that encodes a unique repertoire of proteins governing its survival within the host. Among these are proteins that may activate the next round of cells to be infected, reduce the activation of cells responsible for the inflammatory response, and sabotage the biochemical cascades of host defenses. Never before has a virus held up a mirror so intriguing and so informative.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
621-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Poxviruses: an emerging portrait of biological strategy.
pubmed:affiliation
Department of Cell Biology, Cornell University Medical College, New York, New York 10021.
pubmed:publicationType
Review, Congresses