| pubmed-article:19747996 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0949285 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0023272 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
| pubmed-article:19747996 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:19747996 | pubmed:issue | 48 | lld:pubmed |
| pubmed-article:19747996 | pubmed:dateCreated | 2009-11-2 | lld:pubmed |
| pubmed-article:19747996 | pubmed:abstractText | Canine visceral leishmaniasis is a serious public health concern in the Mediterranean basin since dogs are the main Leishmania infantum reservoir. However, there is not a vaccination method in veterinary use in this area, and therefore the development of a vaccine against this parasite is essential for the possible control of the disease. Previous reports have shown the efficacy of heterologous prime-boost vaccination with the pCIneo plasmid and the poxvirus VV (both Western Reserve and MVA strains) expressing L. infantum LACK antigen against canine leishmaniasis. As pCIneo-LACK plasmid contains antibiotic resistance genes, its use as a profilactic method is not recommended. Hence, the antibiotic resistance gene free pORT-LACK plasmid is a more suitable tool for its use as a vaccine. Here we report the protective and immunostimulatory effect of the prime-boost pORT-LACK/MVA-LACK vaccination tested in a canine experimental model. Vaccination induced a reduction in clinical signs and in parasite burden in the liver, an induction of the Leishmania-specific T cell activation, as well as an increase of the expression of Th1 type cytokines in PBMC and target organs. | lld:pubmed |
| pubmed-article:19747996 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19747996 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747996 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19747996 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19747996 | pubmed:issn | 1873-2518 | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:LarragaVV | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:AlonsoAA | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:CastilloJ AJA | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:PerisAA | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:RamosII | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:MarcenJ MJM | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:AbengozarM... | lld:pubmed |
| pubmed-article:19747996 | pubmed:author | pubmed-author:AlcoleaP JPJ | lld:pubmed |
| pubmed-article:19747996 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19747996 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:19747996 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:19747996 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19747996 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19747996 | pubmed:pagination | 6695-703 | lld:pubmed |
| pubmed-article:19747996 | pubmed:meshHeading | pubmed-meshheading:19747996... | lld:pubmed |
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| pubmed-article:19747996 | pubmed:meshHeading | pubmed-meshheading:19747996... | lld:pubmed |
| pubmed-article:19747996 | pubmed:meshHeading | pubmed-meshheading:19747996... | lld:pubmed |
| pubmed-article:19747996 | pubmed:meshHeading | pubmed-meshheading:19747996... | lld:pubmed |
| pubmed-article:19747996 | pubmed:meshHeading | pubmed-meshheading:19747996... | lld:pubmed |
| pubmed-article:19747996 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19747996 | pubmed:articleTitle | Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection. | lld:pubmed |
| pubmed-article:19747996 | pubmed:affiliation | Centro de Investigaciones Biológicas, Spanish Research Council, Ramiro de Maeztu 9, 28040 Madrid, Spain. | lld:pubmed |
| pubmed-article:19747996 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19747996 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
