Source:http://linkedlifedata.com/resource/pubmed/id/19746409
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1552-485X
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
153B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
695-9
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pubmed:meshHeading |
pubmed-meshheading:19746409-Adult,
pubmed-meshheading:19746409-Alleles,
pubmed-meshheading:19746409-Anorexia Nervosa,
pubmed-meshheading:19746409-Body Mass Index,
pubmed-meshheading:19746409-Case-Control Studies,
pubmed-meshheading:19746409-Female,
pubmed-meshheading:19746409-Genetic Variation,
pubmed-meshheading:19746409-Genotype,
pubmed-meshheading:19746409-Humans,
pubmed-meshheading:19746409-Linkage Disequilibrium,
pubmed-meshheading:19746409-Middle Aged,
pubmed-meshheading:19746409-Polymorphism, Single Nucleotide,
pubmed-meshheading:19746409-Regression Analysis
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pubmed:year |
2010
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pubmed:articleTitle |
Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
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pubmed:affiliation |
Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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