Linked Life Data

19745366

Source:http://linkedlifedata.com/resource/pubmed/id/19745366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-9-11
pubmed:abstractText
In this work, we present a methodology for evaluating an ontology designed in a previous study to describe adverse drug reactions. We evaluate it in term of its fitness for grouping cases in pharmacovigilance. We define as gold standard the Standardized MedDRA Queries (SMQs) developed manually to group terms representing similar medical conditions. We perform an automatic search in the ontology in order to retrieve concepts related to the medical conditions. An optimal query is built for each medical condition. The evaluation relies on the comparison between the terms in the SMQ and the terms subsumed by the query. The result is quantified by sensitivity and specificity. We applied this methodology for 24 SMQs and we obtain a mean sensitivity of 0.82. This work allows validating the semantic resource and provides, in perspective, tools to maintain the ontology while the knowledge is evolving.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
T
pubmed:status
MEDLINE
pubmed:issn
0926-9630
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Evaluation of an ontological resource for pharmacovigilance.
pubmed:affiliation
INSERM, UMR_S 872, eq.20 Paris, France. marie-christine.jaulent@spim.jussieu.fr
pubmed:publicationType
Journal Article, Evaluation Studies