Linked Life Data

1974486

Source:http://linkedlifedata.com/resource/pubmed/id/1974486

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-9-20
pubmed:abstractText
To test the hypothesis of reduced chiasma frequency causing nondisjunction during meiosis, we examined 34 Down syndrome patients and their parents. Chromosomal polymorphisms and RFLP markers were used to trace the parental origin as well as the frequency of recombination of chromosomes 21. In all but one case, the parental origin and the meiotic stage of nondisjunction could be established by either technique. In 11 cases recombination could be deduced to have taken place during meiosis in the parent who contributed the extra chromosome 21. Because of the underestimation which is inherent in the methods used, these results do not seem to support the chiasma theory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9163
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
463-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Rate of recombination of chromosomes 21 in parents of children with Down syndrome.
pubmed:affiliation
Department of Genetics and Cell Biology, University of Limburg, Maastricht, The Netherlands.
pubmed:publicationType
Journal Article