Source:http://linkedlifedata.com/resource/pubmed/id/19744569
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-1-7
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| pubmed:abstractText |
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have a very poor prognosis. However, they may achieve long-term survival by undergoing allogeneic stem cell transplantation (SCT). The purpose of this study was to assess the outcome of all adult patients with DLBCL whose treatment included a reduced-intensity conditioning (RIC) regimen for allogeneic SCT and whose data were reported in the French Society of Marrow Transplantation and Cellular Therapy registry. Sixty-eight patients (median age: 48 years) were transplanted from October 1998 to January 2007. They had received a median of 2 regimens of therapy prior to allogeneic SCT, and 54 (79%) had already undergone SCT. Prior to transplantation, 32 patients (47%) were in complete remission (CR). For all patients but 1, conditioning regimens were based on fludarabine (Flu), which was combined with other chemotherapy drugs in 50 cases (74%) and with total body irradiation (TBI) in 17 (25%). For 56 patients (82%), the donor was an HLA-matched sibling, and peripheral blood was the most widely used source of stem cells (57 patients, 84%). With a median follow-up of 49 months, estimated 2-year overall survival (OS), progression-free survival (PFS), and the cumulative incidence of relapse were 49%, 44%, and 41%, respectively. The 1-year cumulative incidence of nonrelapse mortality (NRM) was 23%. According to multivariate analysis, the patients in CR before transplantation had a significantly longer PFS and a lower CI of relapse than patients transplanted during partial remission or stable or progressive disease. These results suggest that reduced-intensity allergenic transplantation is an attractive therapeutic option for patients with high-risk DLBCL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1523-6536
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| pubmed:author |
pubmed-author:BayJacques-OlivierJO,
pubmed-author:BilgerKarinK,
pubmed-author:BourrhisJean-HenriJH,
pubmed-author:BulaboisClaude-EricCE,
pubmed-author:BuzynAgnèsA,
pubmed-author:CeballosPatriceP,
pubmed-author:ClementLaurenceL,
pubmed-author:ContentinNathalieN,
pubmed-author:CornillonJérômeJ,
pubmed-author:DhedinNathalieN,
pubmed-author:FaucherCatherineC,
pubmed-author:FrançoisSylvieS,
pubmed-author:GuilhotFrançoisF,
pubmed-author:GuillermGaelleG,
pubmed-author:HuynAnneA,
pubmed-author:LarosaFabriceF,
pubmed-author:MichalletMauricetteM,
pubmed-author:MilpiedNoëlN,
pubmed-author:MohtyMohamadM,
pubmed-author:MounierNicolasN,
pubmed-author:RobinMarieM,
pubmed-author:SirventAnneA,
pubmed-author:TabriziRezaR,
pubmed-author:Yakoub-AghaIbrahimI,
pubmed-author:de RevelThierryT
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| pubmed:copyrightInfo |
Copyright (c) 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
78-85
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| pubmed:meshHeading |
pubmed-meshheading:19744569-Adolescent,
pubmed-meshheading:19744569-Adult,
pubmed-meshheading:19744569-Aged,
pubmed-meshheading:19744569-Cohort Studies,
pubmed-meshheading:19744569-Female,
pubmed-meshheading:19744569-France,
pubmed-meshheading:19744569-Graft vs Host Disease,
pubmed-meshheading:19744569-Humans,
pubmed-meshheading:19744569-Incidence,
pubmed-meshheading:19744569-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:19744569-Male,
pubmed-meshheading:19744569-Middle Aged,
pubmed-meshheading:19744569-Recurrence,
pubmed-meshheading:19744569-Registries,
pubmed-meshheading:19744569-Retrospective Studies,
pubmed-meshheading:19744569-Statistics as Topic,
pubmed-meshheading:19744569-Stem Cell Transplantation,
pubmed-meshheading:19744569-Survival Analysis,
pubmed-meshheading:19744569-Transplantation, Homologous,
pubmed-meshheading:19744569-Transplantation Conditioning,
pubmed-meshheading:19744569-Treatment Outcome,
pubmed-meshheading:19744569-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Low nonrelapse mortality and prolonged long-term survival after reduced-intensity allogeneic stem cell transplantation for relapsed or refractory diffuse large B cell lymphoma: report of the Société Française de Greffe de Moelle et de Thérapie Cellulaire.
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| pubmed:affiliation |
Hospital Archet, Nice, France. sirvent.a@chu-nice.fr
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|