Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-10-20
pubmed:abstractText
The study investigated the effects of puerarin on P2X(3) receptor involved in hyperalgesia after burn injury in the rat. Superficial second degree burn injury models were adopted. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured and the P2X(3) receptor expressions in dorsal root ganglion (DRG) from burn injury models rats were detected by immunohistochemistry, in situ hybridization, RT-PCR and western blot. MWL and TWL in untreated superficial second paw burn rats were reduced. MWL and TWL of puerarin-treated superficial second paw burn rats showed significant increase compared with untreated superficial second paw burn rats. Puerarin can decrease the hyperalgesia after burn injury. At day 3 post-burn, the expressions of P2X(3) protein and mRNA in DRG neurons in untreated superficial second degree back burn group were increased significantly compared with sham back burn group, puerarin-treated back unburned control group, blank back control group, while in puerarin-treated superficial second degree back burn group, the P2X(3) protein and mRNA expressions were decreased markedly. There is no significant difference in sham back burn group, puerarin-treated back unburned control group, blank back control group. Therefore, puerarin may reduce the nociceptive transmission of burn injury pain mediated by P2X(3) receptor and alleviate P2X(3) receptor involved in hyperalgesia after burn injury in the rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-2747
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19744545-Animals, pubmed-meshheading:19744545-Burns, pubmed-meshheading:19744545-Disease Models, Animal, pubmed-meshheading:19744545-Ganglia, Spinal, pubmed-meshheading:19744545-Hot Temperature, pubmed-meshheading:19744545-Hyperalgesia, pubmed-meshheading:19744545-Isoflavones, pubmed-meshheading:19744545-Male, pubmed-meshheading:19744545-Neurons, pubmed-meshheading:19744545-Pain Measurement, pubmed-meshheading:19744545-Physical Stimulation, pubmed-meshheading:19744545-RNA, Messenger, pubmed-meshheading:19744545-Random Allocation, pubmed-meshheading:19744545-Rats, pubmed-meshheading:19744545-Rats, Sprague-Dawley, pubmed-meshheading:19744545-Receptors, Purinergic P2, pubmed-meshheading:19744545-Receptors, Purinergic P2X3, pubmed-meshheading:19744545-Time Factors, pubmed-meshheading:19744545-Vasodilator Agents
pubmed:year
2009
pubmed:articleTitle
Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat.
pubmed:affiliation
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't