Linked Life Data

1974331

Source:http://linkedlifedata.com/resource/pubmed/id/1974331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-9-11
pubmed:abstractText
The actions of (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [(+)3-PPP] on sympathetic neurons of the mouse isolated hypogastric ganglion were studied using the current clamp and single electrode voltage clamp techniques. In neurons studied under current clamp (+)3-PPP (10(-5) to 3 x 10(-4) M) evoked a concentration-dependent depolarization, which was fully reversible on washout of the drug. The depolarization was associated with an increase in membrane input resistance. At membrane potentials between -43 and -65 mV the amplitude of the depolarization was inversely related to the membrane potential. (+)3-PPP had no effect on membrane potential at potentials negative to -65 mV. The effect of (+)3-PPP on the M-current was studied in cells voltage clamped at -40 mV and stepped to -60 mV for 300-500 ms. The slow current relaxations seen during and after the voltage step are largely due to the M-current. (+)3-PPP (3 x 10(-5) to 3 x 10(-4) M) inhibited the M-current and produced an inward current in a concentration-dependent manner. (-)3-PPP (3 x 10(-5) M) had similar effects, but was less potent than (+)3-PPP. (+)3-PPP (3 x 10(-5) M) also inhibited the A-current and a calcium-dependent potassium current, but to a lesser degree than the M-current.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Atropine, http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, sigma, http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride, http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium, http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin, http://linkedlifedata.com/resource/pubmed/chemical/n-N-propyl-3-(3-hydroxyphenyl)piperi..., http://linkedlifedata.com/resource/pubmed/chemical/rimcazole
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
725-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1974331-Animals, pubmed-meshheading:1974331-Atropine, pubmed-meshheading:1974331-Carbazoles, pubmed-meshheading:1974331-Dopamine Agents, pubmed-meshheading:1974331-Evoked Potentials, pubmed-meshheading:1974331-Ganglia, Sympathetic, pubmed-meshheading:1974331-Male, pubmed-meshheading:1974331-Membrane Potentials, pubmed-meshheading:1974331-Mice, pubmed-meshheading:1974331-Mice, Inbred DBA, pubmed-meshheading:1974331-Neurons, pubmed-meshheading:1974331-Piperidines, pubmed-meshheading:1974331-Potassium Channels, pubmed-meshheading:1974331-Receptors, Opioid, pubmed-meshheading:1974331-Receptors, sigma, pubmed-meshheading:1974331-Sulpiride, pubmed-meshheading:1974331-Tetraethylammonium, pubmed-meshheading:1974331-Tetraethylammonium Compounds, pubmed-meshheading:1974331-Tetrodotoxin
pubmed:year
1990
pubmed:articleTitle
Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion.
pubmed:affiliation
Department of Pharmacology, University of Cambridge, U.K.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't