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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-10
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pubmed:abstractText |
Low density lipoprotein receptor-related protein 1 (LRP1) protects against atherosclerosis by regulating the activation of platelet-derived growth factor receptor beta (PDGFRbeta) in vascular smooth muscle cells (SMCs). Activated PDGFRbeta undergoes tyrosine phosphorylation and subsequently interacts with various signaling molecules, including phosphatidylinositol 3-kinase (PI3K), which binds to the phosphorylated tyrosine 739/750 residues in mice, and thus regulates actin polymerization and cell movement.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-10500190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-11124809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-11560943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-11739389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-11752634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-12040186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-12598898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-12690199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-12887765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-14580869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-14597676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-1472468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-15044004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-15207812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-15546004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-15767666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-1618748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-16571647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-16601194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-16799921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-16820603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-1713211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-17467262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-17505534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-17652900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-18626063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-2762297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-2779654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-7922352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-8006085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-8107807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-8132765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-8290276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-8349823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-9083025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-9260914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19742316-9645369
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6922
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:19742316-Actins,
pubmed-meshheading:19742316-Animals,
pubmed-meshheading:19742316-Aorta,
pubmed-meshheading:19742316-Cell Movement,
pubmed-meshheading:19742316-Enzyme Activation,
pubmed-meshheading:19742316-Mice,
pubmed-meshheading:19742316-Mice, Inbred C57BL,
pubmed-meshheading:19742316-Mice, Transgenic,
pubmed-meshheading:19742316-Models, Biological,
pubmed-meshheading:19742316-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19742316-Phosphorylation,
pubmed-meshheading:19742316-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:19742316-Receptors, LDL,
pubmed-meshheading:19742316-Signal Transduction,
pubmed-meshheading:19742316-Tumor Suppressor Proteins,
pubmed-meshheading:19742316-Tyrosine
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pubmed:year |
2009
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pubmed:articleTitle |
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.
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pubmed:affiliation |
Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, Texas, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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