Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2009-10-26
pubmed:abstractText
Little is known about the in vivo kinetics of T-cell responses in smallpox/monkeypox. We showed that macaque Vgamma2Vdelta2 T cells underwent 3-week-long expansion after smallpox vaccine immunization and displayed simple reexpansion in association with sterile anti-monkeypox virus (anti-MPV) immunity after MPV challenge. Virus-activated Vgamma2Vdelta2 T cells exhibited gamma interferon-producing effector function after phosphoantigen stimulation. Surprisingly, like alphabeta T cells, suboptimally primed Vgamma2Vdelta2 T cells in vaccinia virus/cidofovir-covaccinated macaques mounted major recall-like expansion after MPV challenge. Finally, Vgamma2Vdelta2 T cells localized in inflamed lung tissues for potential regulation. Our studies provide the first in vivo evidence that viruses, despite their inability to produce exogenous phosphoantigen, can induce expansion, reexpansion, and recall-like expansion of Vgamma2Vdelta2 T cells and stimulate their antimicrobial cytokine response.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-11474428, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-11910108, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-12697454, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-12782281, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-12900516, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-15078924, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-15833080, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-15919938, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-15951823, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16034098, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16170753, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16210655, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16337364, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16586361, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-16652291, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-17152007, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-17709520, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-17923514, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-18056373, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-18539896, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-18802083, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-18981295, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-18981763, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-19004937, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-19383786, http://linkedlifedata.com/resource/pubmed/commentcorrection/19740988-8876063
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1098-5514
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11959-65
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Expansion, reexpansion, and recall-like expansion of Vgamma2Vdelta2 T cells in smallpox vaccination and monkeypox virus infection.
pubmed:affiliation
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural