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rdf:type |
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lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0205132,
umls-concept:C0243102,
umls-concept:C0376202,
umls-concept:C0439857,
umls-concept:C0441889,
umls-concept:C1280500,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1707391,
umls-concept:C2252854,
umls-concept:C2825032,
umls-concept:C2911684
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|
pubmed:issue |
12
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|
pubmed:dateCreated |
2009-12-7
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|
pubmed:abstractText |
Allopregnanolone (ALLO) is a progesterone derivative that rapidly potentiates gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition and modulates symptoms of ethanol withdrawal. Because clinical and preclinical data indicate that ALLO levels are inversely related to symptoms of withdrawal, the present studies determined whether ethanol dependence and withdrawal differentially altered plasma and cortical ALLO levels in mice selectively bred for differences in ethanol withdrawal severity and determined whether the alterations in ALLO levels corresponded to a concomitant change in activity and expression of the biosynthetic enzyme 5alpha-reductase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1530-0277
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2077-87
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:19740134-Administration, Inhalation,
pubmed-meshheading:19740134-Alcoholism,
pubmed-meshheading:19740134-Animals,
pubmed-meshheading:19740134-Brain,
pubmed-meshheading:19740134-Brain Chemistry,
pubmed-meshheading:19740134-Central Nervous System Depressants,
pubmed-meshheading:19740134-Ethanol,
pubmed-meshheading:19740134-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:19740134-Hippocampus,
pubmed-meshheading:19740134-Hydrocortisone,
pubmed-meshheading:19740134-Male,
pubmed-meshheading:19740134-Mice,
pubmed-meshheading:19740134-Mice, Inbred Strains,
pubmed-meshheading:19740134-Oxidoreductases,
pubmed-meshheading:19740134-Pregnanolone,
pubmed-meshheading:19740134-Radioimmunoassay,
pubmed-meshheading:19740134-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19740134-Species Specificity,
pubmed-meshheading:19740134-Substance Withdrawal Syndrome
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pubmed:year |
2009
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pubmed:articleTitle |
Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression.
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pubmed:affiliation |
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. tanchuck@ohsu.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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