Source:http://linkedlifedata.com/resource/pubmed/id/19740090
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2010-2-17
|
| pubmed:abstractText |
The metabotropic glutamate receptor subtype 8 (mGlu(8)) is presynaptically located and regulates the release of the transmitter. Dysfunctions of this mechanism are involved in the pathophysiology of different psychiatric disorders. mGlu(8) deficient mice have been previously investigated in a range of studies, but the results are contradictory and there are still many open questions. Therefore, we tested mGlu(8)-deficient animals in different behavioral tasks that are commonly used in neuropsychiatric research. Our results show a robust contextual fear deficit in mGlu(8)-deficient mice. Furthermore, novel object recognition, chlordiazepoxide-facilitated extinction of operant conditioning and the acoustic startle response were attenuated by mGlu(8) deficiency. We found no changes in sensory processing, locomotor activity, prepulse inhibition, phencyclidine-induced changes in locomotion or prepulse inhibition, operant conditioning, conditioned fear to a discrete cue or in animal models of innate fear and post-traumatic stress disorder. We conclude that mGlu(8) might be a potential target for disorders with pathophysiological changes in brain areas where mGlu(8) modulates glutamate and gamma-amino butyric acid (GABA) transmission. Our data especially point to anxiety disorders involving exaggerated contextual fear, such as generalized anxiety disorders, and to conditions with disturbed declarative memory.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chlordiazepoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Phencyclidine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 8
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1601-183X
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
33-44
|
| pubmed:meshHeading |
pubmed-meshheading:19740090-Animals,
pubmed-meshheading:19740090-Anxiety Disorders,
pubmed-meshheading:19740090-Chlordiazepoxide,
pubmed-meshheading:19740090-Conditioning, Operant,
pubmed-meshheading:19740090-Conditioning (Psychology),
pubmed-meshheading:19740090-Disease Models, Animal,
pubmed-meshheading:19740090-Extinction, Psychological,
pubmed-meshheading:19740090-Fear,
pubmed-meshheading:19740090-Hyperkinesis,
pubmed-meshheading:19740090-Maze Learning,
pubmed-meshheading:19740090-Mice,
pubmed-meshheading:19740090-Mice, Inbred C57BL,
pubmed-meshheading:19740090-Mice, Knockout,
pubmed-meshheading:19740090-Motor Activity,
pubmed-meshheading:19740090-Pattern Recognition, Visual,
pubmed-meshheading:19740090-Phencyclidine,
pubmed-meshheading:19740090-Receptors, Metabotropic Glutamate,
pubmed-meshheading:19740090-Startle Reaction
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
The effect of mGlu8 deficiency in animal models of psychiatric diseases.
|
| pubmed:affiliation |
Novartis Institutes for BioMedical Research, Neuroscience DA, 4056 Basel, Switzerland. markus.fendt@novartis.com
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|