Linked Life Data

19739642

Source:http://linkedlifedata.com/resource/pubmed/id/19739642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2009-10-7
pubmed:abstractText
Dietary proteins influence the lipid metabolism of human subjects and animals. This study evaluated the effects of fish protein on lipid metabolism in rats. Alaska pollock fillets, widely supplied as raw materials of surimi, were used as fish protein. As parameters of lipid metabolism, cholesterol and triacylglycerol concentrations in the serum and liver, the fecal excretion of bile acids, and the hepatic expression of genes encoding proteins involved in lipid homeostasis were examined. Rats fed fish protein showed decreased cholesterol concentrations in the serum and liver, and fecal bile acid and cholesterol concentrations were increased. This was caused by the increased expression of cholesterol 7alpha-hydroxylase (CYP7A1) as the digested fish protein inhibited the absorption of bile acid and cholesterol in the small intestine. In addition, it was found that dietary fish protein affects the farnesoid X receptor/small heterodimer partner-dependent pathway, which is negatively regulated by the decreased reabsorption of bile acid. Furthermore, it increased the binding to the promoter of CYP7A1 through activated liver receptor homologue-1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1520-5118
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9256-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism.
pubmed:affiliation
Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
pubmed:publicationType
Journal Article