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pubmed-article:19739129pubmed:abstractTextWe have previously reported that finasteride administration in intermittent androgen deprivation therapy (IADT) can improve survival of nude mice bearing LNCaP xenograft tumors when the duration of off-cycle in IADT was fixed. A recent retrospective study showed that addition of finasteride doubled the duration of the off-cycle, without changing progression to castration resistance. In view of the above difference, we attempted to investigate the relationship of 5alpha-reductase inhibition with the off-cycle interval and overall survival in a murine model.lld:pubmed
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pubmed-article:19739129pubmed:articleTitleProlongation of off-cycle interval by finasteride is not associated with survival improvement in intermittent androgen deprivation therapy in LNCaP tumor model.lld:pubmed
pubmed-article:19739129pubmed:affiliationDepartment of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.lld:pubmed
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