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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-12-28
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pubmed:abstractText |
We have previously reported that finasteride administration in intermittent androgen deprivation therapy (IADT) can improve survival of nude mice bearing LNCaP xenograft tumors when the duration of off-cycle in IADT was fixed. A recent retrospective study showed that addition of finasteride doubled the duration of the off-cycle, without changing progression to castration resistance. In view of the above difference, we attempted to investigate the relationship of 5alpha-reductase inhibition with the off-cycle interval and overall survival in a murine model.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-10235151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-11444528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-12581889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-12667885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-12907652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-14572746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-14684610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-16215305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-16372330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-16600727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-16631455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-17186528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-17662079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-17706711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-2126735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-3724177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-7682149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19739129-8809195
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-54
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:19739129-Androgen Antagonists,
pubmed-meshheading:19739129-Androgens,
pubmed-meshheading:19739129-Animals,
pubmed-meshheading:19739129-Cell Cycle,
pubmed-meshheading:19739129-Cell Line, Tumor,
pubmed-meshheading:19739129-Dihydrotestosterone,
pubmed-meshheading:19739129-Enzyme Inhibitors,
pubmed-meshheading:19739129-Estradiol,
pubmed-meshheading:19739129-Finasteride,
pubmed-meshheading:19739129-Male,
pubmed-meshheading:19739129-Mice,
pubmed-meshheading:19739129-Mice, Inbred BALB C,
pubmed-meshheading:19739129-Mice, Nude,
pubmed-meshheading:19739129-Orchiectomy,
pubmed-meshheading:19739129-Prostatic Neoplasms,
pubmed-meshheading:19739129-Survival Analysis,
pubmed-meshheading:19739129-Testosterone,
pubmed-meshheading:19739129-Time Factors,
pubmed-meshheading:19739129-Xenograft Model Antitumor Assays
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pubmed:year |
2010
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pubmed:articleTitle |
Prolongation of off-cycle interval by finasteride is not associated with survival improvement in intermittent androgen deprivation therapy in LNCaP tumor model.
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pubmed:affiliation |
Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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