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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-12-7
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pubmed:abstractText |
A history of early adverse life events (EALs) is associated with a poorer outcome and higher levels of distress in adult patients with functional gastrointestinal disorders. An EAL is thought to predispose individuals to develop a range of chronic illnesses by inducing persistent changes in the central stress response systems, including the hypothalamic-pituitary-adrenal (HPA) axis. We sought to determine if EALs affect the HPA axis response to a visceral stressor in irritable bowel syndrome (IBS) patients and healthy controls, and to determine if this is affected by sex or related to symptoms or quality of life.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1954-62
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:19737564-Adult,
pubmed-meshheading:19737564-Case-Control Studies,
pubmed-meshheading:19737564-Female,
pubmed-meshheading:19737564-Humans,
pubmed-meshheading:19737564-Hydrocortisone,
pubmed-meshheading:19737564-Hypothalamo-Hypophyseal System,
pubmed-meshheading:19737564-Irritable Bowel Syndrome,
pubmed-meshheading:19737564-Life Change Events,
pubmed-meshheading:19737564-Male,
pubmed-meshheading:19737564-Middle Aged,
pubmed-meshheading:19737564-Pituitary-Adrenal System,
pubmed-meshheading:19737564-Quality of Life,
pubmed-meshheading:19737564-Questionnaires,
pubmed-meshheading:19737564-Risk Factors,
pubmed-meshheading:19737564-Saliva,
pubmed-meshheading:19737564-Severity of Illness Index,
pubmed-meshheading:19737564-Sex Factors,
pubmed-meshheading:19737564-Sigmoidoscopy,
pubmed-meshheading:19737564-Stress, Psychological,
pubmed-meshheading:19737564-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome.
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pubmed:affiliation |
Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7378, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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