Linked Life Data

19737000

Source:http://linkedlifedata.com/resource/pubmed/id/19737000

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
2009-9-24
pubmed:abstractText
Molecular dynamics simulations have been carried out to investigate the dynamics of fructose aqueous solutions up to 70 wt % concentration. We find that the hydrogen (H)-bonded network of fructose molecules extends with increasing sugar content and forms a structurally heterogeneous system around and above 45 wt % concentration, characterized as a percolated-like solute domain permeated by patchy regions of solvent. The presence of such aggregates in concentrated solutions promotes the slowing down of water translational, reorientational, and H-bonding dynamics, typical of many biomolecular environments. Analysis of the effects of the topological and energetic disorder of the sugar aggregates on vicinal water dynamics, similar to that recently carried out for the hydration layer of proteins by Pizzitutti et al. (J. Phys. Chem. B 2007, 111, 7584), reveals many similarities between the dynamical anomaly of the hydration layers of both systems. Like a protein surface, topological and energetic disorders of the sugar aggregates both contribute to the translational diffusion anomaly. However, unlike in the vicinity of a protein surface, the rotational relaxation is also hindered by the topological disorder created by the intertwined, percolating sugar clusters in concentrated solutions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1520-5207
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12999-3006
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Anomalous dynamics of hydration water in carbohydrate solutions.
pubmed:affiliation
Departamento de Física, Comisión Nacional de Energía Atómica, Avenida Gral. Paz 1499 (1650) San Martín, Buenos Aires, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't