| pubmed-article:19736928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0292688 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C1336624 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:19736928 | lifeskim:mentions | umls-concept:C0332306 | lld:lifeskim |
| pubmed-article:19736928 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:19736928 | pubmed:dateCreated | 2009-12-3 | lld:pubmed |
| pubmed-article:19736928 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:abstractText | A novel class of 4-pyridinoxy-2-anilinopyridine-based TGF-beta type I receptor (also known as activin-like kinase 5 or ALK5) inhibitors is reported. The binding mode of this scaffold was successfully predicted by analyzing possible docked binding modes of literature inhibitors and novel synthetic ideas. Compounds such as 19 are potent ALK5 inhibitors with good physicochemical and pharmacokinetic properties and thus represent high quality leads for further optimization. | lld:pubmed |
| pubmed-article:19736928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19736928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19736928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19736928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19736928 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19736928 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:McIntyreS SSS | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:WardRichard... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:NormanRichard... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:DebreczeniJud... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:RobertsNicola... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:GoldbergFrede... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:PowellSteven... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:DishingtonAll... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:GingellHelen... | lld:pubmed |
| pubmed-article:19736928 | pubmed:author | pubmed-author:RobertsAndrew... | lld:pubmed |
| pubmed-article:19736928 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19736928 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:19736928 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19736928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19736928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19736928 | pubmed:pagination | 7901-5 | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
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| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:meshHeading | pubmed-meshheading:19736928... | lld:pubmed |
| pubmed-article:19736928 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19736928 | pubmed:articleTitle | Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5). | lld:pubmed |
| pubmed-article:19736928 | pubmed:affiliation | AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK. | lld:pubmed |
| pubmed-article:19736928 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19736928 | lld:chembl |
