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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1990-8-30
|
| pubmed:abstractText |
An early molecular event in the evolution of insulin-dependent diabetes in humans and NOD mice appears to involve the interaction of MHC class II molecules, beta-cell autoantigen-derived peptides, and receptor molecules of helper T lymphocytes. To examine the influence of T-lymphocyte-receptor beta-genes on the development of beta-cell autoimmunity, (NOD x NZW)F1 x NOD backcrossed (BC) mice were studied for the development of insulitis, because insulitis is the pathognomonic histological lesion of autoimmune diabetes. Heterozygosity for H-2nod was permissive for the development of pancreatic interstitial inflammation and peri-islet insulitis, whereas homozygosity for H-2nod was highly associated with insulitis. However, (NOD x NZW)F1 x NOD BC mice developed insulitis regardless of homozygosity or heterozygosity for T-lymphocyte receptor beta nod. Therefore, in our study, T-lymphocyte receptor beta nod did not function as an autosomal-recessive beta-cell autoimmunity gene.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
975-82
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1973674-Animals,
pubmed-meshheading:1973674-Autoimmune Diseases,
pubmed-meshheading:1973674-Autoimmunity,
pubmed-meshheading:1973674-Cell Movement,
pubmed-meshheading:1973674-Cross-Sectional Studies,
pubmed-meshheading:1973674-Diabetes Mellitus,
pubmed-meshheading:1973674-Diabetes Mellitus, Experimental,
pubmed-meshheading:1973674-Diabetes Mellitus, Type 1,
pubmed-meshheading:1973674-Disease Susceptibility,
pubmed-meshheading:1973674-Female,
pubmed-meshheading:1973674-H-2 Antigens,
pubmed-meshheading:1973674-Inflammation,
pubmed-meshheading:1973674-Islets of Langerhans,
pubmed-meshheading:1973674-Male,
pubmed-meshheading:1973674-Mice,
pubmed-meshheading:1973674-Obesity,
pubmed-meshheading:1973674-Pancreatic Diseases,
pubmed-meshheading:1973674-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1973674-Receptors, Antigen, T-Cell,
pubmed-meshheading:1973674-Receptors, Antigen, T-Cell, alpha-beta
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Immunogenetic analysis of beta-cell autoimmunity in NOD mice. Relationship of insulitis to T-lymphocyte-receptor beta nod and A beta nod genes.
|
| pubmed:affiliation |
Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|