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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1 Pt 1
|
| pubmed:dateCreated |
1990-8-23
|
| pubmed:abstractText |
The influence of fasting on the dual adrenergic control of adipose tissue lipolysis was investigated in hamsters because in this species the adipocytes exhibit both beta-stimulatory and alpha 2-inhibitory adrenergic responses. In adipocytes from fed animals, the number of alpha 2-receptors (identified with [3H]clonidine and [3H]RX 821002) was greater than that of beta-receptors. As in humans, the alpha 2-adrenoceptor number was greater in adipocyte membranes from subcutaneous (inguinal and popliteal) than from internal (perirenal and epididymal) adipose tissues. Despite this difference in alpha 2-adrenoceptor number, the antilipolytic responses to the alpha 2-agonists clonidine and UK 14304 were similar in the two tissues. Food deprivation for a period of 1-6 days induced a net depletion of both adipose tissues. In 6-day starved animals the number of adipocyte alpha 2-adrenoceptors and the maximal antilipolytic effect of UK 14304 were less than 50% of those in fed controls. In contrast, the antilipolytic responses to phenylisopropyladenosine or prostaglandin E1 remained unchanged. Starvation induced a decrease in alpha 2-adrenoceptor number and an increase in beta-adrenergic sensitivity that were greater in adipocytes from subcutaneous than from internal fad pads. The data suggest that the adipocyte beta- and alpha 2-adrenoceptors are independently regulated during starvation. In the adipocyte, the alpha 2-antilipolytic responses and the alpha 2-adrenoceptor levels are dependent on the extent of the adipose mass; they are particularly reduced in emaciated hamsters.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Deaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Alprostadil,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylisopropyladenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/brimonidine
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
259
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E80-8
|
| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:1973602-Adenosine Deaminase,
pubmed-meshheading:1973602-Adipose Tissue,
pubmed-meshheading:1973602-Adrenergic beta-Agonists,
pubmed-meshheading:1973602-Alprostadil,
pubmed-meshheading:1973602-Animals,
pubmed-meshheading:1973602-Blood Proteins,
pubmed-meshheading:1973602-Cells, Cultured,
pubmed-meshheading:1973602-Clonidine,
pubmed-meshheading:1973602-Cricetinae,
pubmed-meshheading:1973602-Fatty Acids, Nonesterified,
pubmed-meshheading:1973602-Lipolysis,
pubmed-meshheading:1973602-Male,
pubmed-meshheading:1973602-Mesocricetus,
pubmed-meshheading:1973602-Phenylisopropyladenosine,
pubmed-meshheading:1973602-Quinoxalines,
pubmed-meshheading:1973602-Receptors, Adrenergic, beta,
pubmed-meshheading:1973602-Reference Values,
pubmed-meshheading:1973602-Starvation
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Selective reduction of alpha 2-adrenergic responsiveness in hamster adipose tissue during prolonged starvation.
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| pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale, U 317, Toulouse, France.
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| pubmed:publicationType |
Journal Article
|