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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2009-9-28
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pubmed:abstractText |
Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BroadrupRobert LRL,
pubmed-author:BrogdonBerniceB,
pubmed-author:CasselJoel AJA,
pubmed-author:ChuGuo-HuaGH,
pubmed-author:DeHavenRobert NRN,
pubmed-author:DolleRoland ERE,
pubmed-author:GoodmanAllan JAJ,
pubmed-author:KoblishMichaelM,
pubmed-author:LaBudaChristopher JCJ,
pubmed-author:Le BourdonnecBertrandB,
pubmed-author:SaeuiChristopher TCT,
pubmed-author:SmithSteveS,
pubmed-author:WeaverDamian GDG,
pubmed-author:WormKarinK
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5931-5
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pubmed:meshHeading |
pubmed-meshheading:19736007-Administration, Oral,
pubmed-meshheading:19736007-Aminopyridines,
pubmed-meshheading:19736007-Animals,
pubmed-meshheading:19736007-Dogs,
pubmed-meshheading:19736007-Humans,
pubmed-meshheading:19736007-Male,
pubmed-meshheading:19736007-Microsomes, Liver,
pubmed-meshheading:19736007-Morpholines,
pubmed-meshheading:19736007-Pain,
pubmed-meshheading:19736007-Protein Binding,
pubmed-meshheading:19736007-Pyridines,
pubmed-meshheading:19736007-Rats,
pubmed-meshheading:19736007-Rats, Sprague-Dawley,
pubmed-meshheading:19736007-Receptor, Cannabinoid, CB1,
pubmed-meshheading:19736007-Receptor, Cannabinoid, CB2,
pubmed-meshheading:19736007-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.
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pubmed:affiliation |
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. ghchu@adolor.com
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pubmed:publicationType |
Journal Article
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